منابع مشابه
P-43: Reproductive Toxicity of Low Metal Exposureon Male
Background: Recent evidence has indicated a deterioration in reproductive health of men in many countries over the past few decades, particularly a decrease in semen quality and an increase in prevalence of prostate cancer. The human male has a relatively low fertility potential as compared to other mammals. Thus, the human male may be at greater risk from reproductive toxicants. For example, t...
متن کاملOxidative Stress on Male Reproductive Toxicity
Globally Harmonized System defines Reproductive Toxicity as “an adverse effects (of chemicals) on sexual function and fertility in adult males and females, as well as developmental toxicity in the offspring.” Several toxicity assessment studies have been performed taking into account the action of toxicants on reproductive activity. Testis is the main organ of male reproductive system and sperm...
متن کاملAssessing Male Reproductive Toxicity during Drug Development
Male infertility accounts for about 50% of infertility cases [1]. Anatomic, genetic, endocrinological, environmental, behavioral and nutritional imbalances are critical causes of male infertility [2-5]. Therapeutic drugs can also adversely affect male fertility by injuring testicular cells or instigate hormonal changes that lead to decreased semen quality (Figure 1) thereby compromising the pro...
متن کاملChanges in Reproductive Hormones Secretion Involved in Quantum Dots-induced Reproductive Toxicity in Adult Male Mice
Background and Aims: Quantum dots (QDs), as colloidal nanocrystalline semiconductors, present QD wavelengths in terms of biomedical assays and imaging, though the high toxicity of their core demands to be taken into consideration. Investigating this subject is taken into account as an important concept concerning use of these nanoparticles in the medical applications. Materials a...
متن کاملAny need to revisit the male reproductive toxicity of lead?
T he toxicity of lead has been known for millennia and has served as a template for toxicology studies. According to some 45 000 measurements in European industrial settings spanning smelters, battery manufacturing, and foundries, the average concentration of lead in blood steadily declined from 68 mg/dl in 1970 to 35 mg/dl in 1995. In parallel with this development the introduction of non-lead...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 2001
ISSN: 0192-6233,1533-1601
DOI: 10.1080/019262301301418865